Assessing Radiologic Changes

Possible Usual Interstitial Pneumonia Pattern on HRCT, Small

Used with permission from McGraw-Hill Companies, Inc. Copyright © 2007 McGraw-Hill Companies, Inc.

High-Resolution Computed Tomography

Progression of fibrosis from baseline, as visualized by HRCT, is indicative of disease progression in patients with IPF.1 Honeycombing and fibrosis observed on HRCT scan were strongly correlated with pulmonary function.27 Furthermore, a relationship between specific features observed on HRCT and survival has been suggested by several studies. In particular these studies have shown that the extent of honeycombing and fibrosis may predict survival.15161718 The role of HRCT in the diagnosis of IPF is clear, but there are no definitive recommendations regarding HRCT for routine monitoring of IPF disease progression in clinical practice.1 This is largely due to uncertainty over whether it adds additional prognostic information to the IPF symptoms review and spirometry with DLCO.1 For more information about the role of HRCT in the diagnosis of IPF, see Diagnosis and Natural History

Content contributed by:
Ryan Hadley, MD
University of Michigan